​Services provided by PPP have expanded greatly since the founding of the organization

Prevention Point Philadelphia began syringe exchange operations in North Philadelphia in 1991. At the time, PPP was an underground, grassroots outgrowth of the Philadelphia chapter of ACT UP (AIDS Coalition to Unleash Power). PPP was also supported by the Friends neighborhood Guild. At the time, the possession of syringes was illegal in the City of Philadelphia. In 1992, after lobbying efforts by the members of PPP, Mayor Ed Rendell issued an Executive Order (4-92), legalizing the possession of syringes in Philadelphia, overriding the laws of Pennsylvania, which are still in existence today. Since then PPP has expanded its physical space from an office in Health Center #3 to a basement on Lehigh Avenue to its current location on Kensington Avenue. More importantly, however, the breadth of services provided by PPP has also greatly expanded from syringe exchange to now include services ranging from case management and free medical care to overdose prevention and the provision of naloxone.